Table of Contents

Volume 1. Preface. Color Plates. 1 Structure and Function. 1 X-Ray Diffraction of Biological Macromolecules (Albrecht Messerschmidt Robert Huber). 2 Protein NMR Spectroscopy (Thomas Szyperski). 3 Electron Microscopy of Biomolecules (Claus-Thomas Bock, Susanne Franz, Hanswalter Zentgraf, and John Sommerville). 4 Circular Dichroism in Protein Analysis (Zhijing Dang and Jonathan D. Hirst). 5 Protein Structure Analysis: High-throughput Approaches (Andrew P. Turnbull Udo Heinemann). 6 Protein Aggregation (Jeannine M. Yon). 7 Prions (Stanley B. Prusiner). 8 Alzheimer'sDisease (Jun Wang, Silva Hecimovic and Alison Goate). 9 Molecular Chaperones (Peter Lund). 10 Motor Proteins (CharlesL. AsburyStevenM. Block). 11 DNA-Protein Interactions (Sylvie Rimsky and Malcolm Buckle). 2 ModelingandDesign. 12 Protein Modeling (Marian R. Zlomislic D. Peter Tieleman). 13 Synthesis of Peptide Mimetics and their Building Blocks (Bruce K. Cassels Patricio Saaez). 14 Design and Application of Synthetic Peptides (Gregory A. Grant). 15 Synthetic Peptides: Chemistry, Biology, and Drug Design (Tomi K. Sawyer). 3 Expression, Synthesis and Degradation. 16 Ribosome, High Resolution Structure and Function (Christiane Schaffitzel Nenad Ban). 17 Ubiquitin-Proteasome System for Controlling Cellular Protein Levels (Michael H. Glickman Aaron Ciechanover). 18 Plant-based Expression of Biopharmaceuticals (Jorg Knablein). 19 Cell-free Translation Systems (Takuya Ueda, Akio Inoue and Yoshihiro Shimizu). Volume 2. Preface. Color Plates. 4 Analytical Techniques. 20 HPLC of Peptides and Proteins (Tzong-Hsien Lee Marie-Isabel Aguilar). 21 Protein Purification (Richard R. Burgess). 22 Gel Electrophoresis, 2D-difference (John F. Timms). 23 Proteomics (Hiroyuki Matsumoto, Sadamu Kurono, Masaomi Matsumoto, Naoka Komori). 24 Mass Spectrometry-based Methods of Proteome Analysis (Boris L. Zybailov Michael P. Washburn). 25 Protein Microarrays (Jens R. Sydor, David S. Wilson, Steffen Nock). 26 Computational Biology (Thomas Lengauer). 27 Single DNA, RNA and Protein Molecules at Work (Karl Otto Greulich). 28 Footprinting Methods to Examine the Structure and Dynamics of Proteins (Jing-Qu Guan and Mark R. Chance). 5 Signaling and Regulation. 29 Biological Regulation by Protein Phosphorylation (Clay W. Scott, Ratan V. Bhat, and Gaochao Tian). 30 Intracellular Signaling in Cancer (Chittam U. Thakore, Brian D. Lehmann, James A. McCubrey, David M. Terrian). 31 Receptor Biochemistry (Tatsuya Haga Kimihiko Kameyama). 32 Signal Transduction Mediated by Heptahelical Receptors and Heterotrimeric G Proteins (Terence E. Hebert, John K. Northup, R. Victor Rebois). 33 Growth Factors (Antony W. Burgess). 34 Interleukins (Anthony Meager). 35 Viral Inhibitors and Immune Response Mediators: The Interferons (Anthony Meager). 36 Molecular Mediators: Cytokines (Jean-Marc Cavaillon). Cumulative List of Contributors. Subject Index.

About the Author

Robert A. Meyers obtained his Ph.D. in Chemistry at the University of California at Los Angeles. He was a post-doctoral fellow at the California Institute of Technology and has more than 17 patents, 50 technical papers and 12 books to his name. As Editor-in-Chief he conceived and edited several ambitious multivolume reference works, e.g. the Encyclopedia of Analytical Chemistry (Wiley), the preceding Encyclopedia of Molecular Biology and Molecular Medicine (VCH) and the Encyclopedia of Physical Science and Technology (Academic Press).

Reviews

'With three Nobel laureates contributing to this collection, these two volumes cover a wide range of topics in protein research.' (Anticancer Research, 2007)