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The Psychosis-risk Syndrome
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Table of Contents

PART A: Psychosis-Risk Syndromes for First Psychosis: Background 1 1. Psychosis-Risk Syndromes for First Psychosis: A History of the Concept 3 2. Development of the Structured Interview for Psychosis-Risk Syndromes (SIPS) 10 3. Reliability and Validity of the SIPS 17 4. Symptom Classes and Factors in the SIPS 21 5. Psychosis-Risk Syndromes and Psychosis in the SIPS 24 6. The "Other" Symptoms of the Risk Syndromes: Negative, Disorganization, and General 33 7. Characteristics of SIPS Psychosis-Risk Samples 36 PART B: Psychosis-Risk Syndromes: SIPS and SOPS Evaluation 45 8. Pathways to the Risk Syndrome Clinic 47 9. Initial Interview: The SIPS and SOPS Evaluation 49 10. Initial Evaluation: Informing Patients and Families of Risk Status and Options 59 11. Rating Positive and Other Psychosis-Risk Symptoms with the SOPS 63 12. Rating Actual Cases, Baseline Assessment 78 13. Differential Diagnosis of the Psychosis-Risk Syndrome 109 14. Psychosis-Risk Patients over Time 120 15. Rating Baseline Cases for Practice 139 PART C: The PRIME Clinic: Psychosis-Risk Patients Face-to-Face 161 Bibliography 169 Appendixes A. Risk Syndrome Phone Screen 174 B. SIPS/SOPS 5.0 179 C. Informed Consent 237

About the Author

Thomas H. McGlashan MD, Founder, PRIME Research Clinic, Professor, Department of Psychiatry, Yale University, New Haven, CT, USA Barbara Walsh PhD, Clinical Coordinator, PRIME Research Clinic, Department of Psychiatry, Yale University, New Haven, CT, USA Scott Woods MD, Director, PRIME Research Clinic, Department of Psychiatry, Yale University, New Haven, CT, USA

Reviews

"This is a valuable new tool in the effort to detect individuals at risk for psychosis. It provides keen insights into developing similar detection programs." --Doody's

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