Section 1: General Systems Genetics
1. Why Study the Systems Genetics of Sport and Exercise?
2. Expansion of Knowledge and Advances in Genetics for Quantitative Analyses
3. Human Systems Genetic Modeling Used in Exercise
4. The Translation of Systems Genetics of Exercise to Everyday Life
Section 2: Systems Genetics of Physical Activity
5. Is Physical Activity Regulated by Genetics? Evidence from Animal Models
6. Is Physical Activity Regulated by Genetics? Evidence from Studies in Humans
7. The Evolution of Genetic Mechanisms Controlling Physical Activity
8. Neurogenetics of Motivation for Physical Activity
9. Peripheral Mechanisms Arising from Genetics that Regulate Activity
10. Toxicant and Dietary Exposures as Unique Environmental Factors that Affect the Genetic Regulation of Activity
Section 3: Systems Genetics of Exercise Endurance and Trainability
11. The Evolution of the Human Endurance Phenotype
12. Endurance Phenotype Primer
13. Heritability of Endurance Traits from Animal Research Models
14. Heritability of Endurance Traits from Human Research Models
15. Genetic Contributions to Cardiorespiratory Fitness
16. Genetic Contributions to Mitochondrial Traits
17. Angiotensin-Converting Enzyme and the Genomics of Endurance Performance
Section 4: Systems Genetics of Muscle Mass, Strength, and Trainability
18. Heritability of Muscle Size and Strength Traits
19. Genetic Contributions to Muscle Strength
20. Genetic Contributions to Skeletal Muscle Size
21. Genetic Contributions to Neuroendocrine Response to Resistance Training
22. Myostatin’s Role in Genetic Control of Muscle Size and Strength
23. Alpha-Actinin-3’s Role in the Genetic Control of Muscle Strength and Performance
Section 5: Systems Genetics of Sports Performance
24. Summary Findings on Genetics and Sport Performance
25. Using Elite Athletes as a Model for Genetic Research
26. Twin and Family Studies in Sport Performance
27. Sport Concussion Genetics
28. Systems Genetic Factors Underlying Soft Tissue Injury
29. Sex and Performance: Nature Versus Nurture
Section 6: The Ethics of Systems Genetics in Exercise and Sport
30. Race and Sports Performance
31. The Scientific and Ethical Challenges of Using Genetic Information to Predict Sport Performance
32. Gene Doping: Ethical Perspectives
33. Enhancing Evolution: The Transhuman Case For Gene Doping
34. The Ethics of Sex Testing in Sport
Section 7: Conclusions
35. Exercise Genomics, Epigenomics, and Transcriptomics: A Reality Check!
36. Afterword - Closing the Loop: Observations and Conclusions
J. Timothy Lightfoot is the Omar Smith Endowed Chair in Kinesiology and the Director of the Sydney and JL Huffines Institute for Sports Medicine and Human Performance at Texas A&M University in College Station, Texas (USA), and holds the rank of Professor of joint appointments on the Texas A&M Genetics Faculty and the Texas A&M Institute for Genome Sciences and Society. His research focus has been the genetic factors that regulate daily physical activity. He is an Associate Editor of Medicine and Science in Sports and Exercise. He was a founding member of the National Exercise Clinical Trials Network and is a Fellow of the American College of Sports Medicine.
Monica J. Hubal is an Associate Professor of Kinesiology at Indiana University–Purdue University Indianapolis, USA. She is also an Adjunct Associate Professor of Cellular and Integrative Physiology, a research scientist in the Diabetes Translational Research Center and is affiliated with the Indiana Center for Musculoskeletal Health at the Indiana University School of Medicine. Her research focuses on understanding the systems biology of emergent cardiometabolic disease and the mechanisms driving response to various interventions. She was a principal investigator in the Research Center for Genetic Medicine at the Children’s National Medical Center. She is an Associate Editor for Medicine and Science in Sports and Exercise and Exercise and Sport Sciences Reviews and is a Fellow of the American College of Sports Medicine.
Stephen M. Roth is a Professor of Kinesiology and Associate Dean at the University of Maryland in College Park, USA. He has researched the genetic aspects of exercise and sport for over 15 years. He is an author or co-author of over 90 peer-reviewed articles, book chapters, and books. He served as an Associate Editor for Medicine and Science in Sports and Exercise and Exercise and Sport Sciences Reviews. He is a Fellow of the National Academy of Kinesiology and the American College of Sports Medicine.
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