Table of Contents

1 Mendelism.- Basic Probability: Methods for Analyzing Mendelian Genetics.- Forked Line Method.- Mendel’s Data.- Crosses Involving Three or More Gene Pairs.- Goodness of Fit Testing.- Subdividing Chi Square.- Gene Interaction.- Distinguishing Among Genetic Ratios.- Double Fertilization in Plants.- Additional Plant Genetics Considerations.- Problems.- Solutions.- Reference.- 2 Sex Determination and Sex Linkage.- General Aspects of Mating Systems.- XX/XY Chromosome System.- Sex Ratios.- Binomial Statistics.- Haploid-Diploid Sex Determination.- Sex Linkage.- Pedigrees.- Partial Sex-Linkage.- Problems.- Solutions.- 3 Chromosomes and Cell Division.- Chromosomes.- The Cell Cycle.- Further Analysis of the Cell Cycle.- Percent Labeled Mitoses Method.- Mitosis.- Meiosis.- Genetic Diversity.- C Values.- Problems.- Solutions.- 4 Linkage, Recombination, and Mapping.- Exceptions to Independent Assortment.- Recombination Values and Genetic Maps.- Three-Point Tests.- Mapping Concepts.- Recombination Calculated with F2 Data.- Haploid Genetics.- Tetrad Analysis.- Tetrad Analysis and Gene Mapping.- Problems.- Solutions.- Reference.- 5 Variations in Chromosome Number and Structure.- Types of Chromosome Variation.- Aneuploidy.- Polyploidy.- Deletions and Duplications.- Inversions.- Translocations.- Other Aberrations.- Problems.- Solutions.- 6 Quantitative Inheritance.- Continuous Variation.- Polygenes.- Estimating Number of Gene Pairs Involved in Quantitative Traits.- Variance.- Broad Sense Heritability.- Narrow Sense Heritability.- Heterosis.- Thresholds.- Mapping Quantitative Traits.- Problems.- Solutions.- Reference.- 7 Population Genetics.- Concept of Gene Pools.- Gene and Genotype Frequencies.- Hardy-Weinberg Principle.- Hardy-Weinberg Equilibrium.- Extensions of Hardy-WeinbergRelationships.- Genetic Drift.- Migration.- Mutation.- Selection.- A Statistical Approach to Change in a Population.- Nonrandom Mating.- Problems.- Solutions.- References.- 8 Gene Concepts.- One-Gene One-Enzyme.- Allelism.- Bacterial Genetics.- Bacteriophages.- Complementation.- Genetic Fine Structure Analysis in Bacteriophages.- Genetic Fine Structure Analysis in Other Organisms.- Problems.- Solutions.- References.- 9 Molecular Basis of Heredity.- Nucleic Acids.- Nearest Neighbor Frequency Analysis.- Central Dogma.- Semiconservative Mode of Replication.- Replication Forks and Okazaki Fragments.- Transcription.- Proteins.- Translation.- Genetic Code.- Regulation.- Operon Systems.- Mutation.- Mutation Detection.- Problems.- Solutions.- References.- 10 Non-Mendelian Inheritance.- Cytoplasmic Inheritance.- Male Sterility in Plants.- Maternal Effects.- Genomic Imprinting.- DNA Trinucleotide Repeats.- Meiotic Drive.- B Chromosomes.- Problems.- Solutions.- 11 Human Genetics.- Mendelian Inheritance in Humans.- Bias of Ascertainment.- Epidemiology and Pedigrees.- Linkage Analysis—Classical Approaches.- Physical Mapping.- Human Genome Project.- Population Genetics.- Testing Inheritance of a Single Allelic Pair in a Population.- Consanguinity.- Methods of Studying the Genetic Basis of Behavior in Humans.- Twin Studies and Concordance.- Problems.- Solutions.- References.- 12 Additional Genetic Analysis Using Statistics.- More Probability.- Permutations and Combinations.- The Binomial Distribution.- Poisson Distribution.- Contingency Tables—Test for Independence.- Problems.- Solutions.

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