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" Spikes is a masterful account of a methodology that has become essential for anyone studying how neuronal spiking patterns encode information. New results and techniques are clearly and insightfully presented and placed within the historical context of earlier work. Both this book and the techniques described in it are likely to become classics in the field." -- L. F. abbott, Volan Center for Complex Systems, Brandeis University " Spikes is an ode to the single spike, where it points to, what information it carries and how reliable it is. It is quite pleasing to see innovative concepts from the sixties and seventies mature and being integrated into a powerful method to quantify nervous system action. The various digressions and inside physicist's puns makes this book a joy to read. Mandatory for neuroscientists not afraid of a quantitative approach and wanting to replace hand waving with numbers." -- Jos J. Eggermont, Alberta Heritage Medical Scientist; Professor, Department of Psychology, The University of Calgary " Spikes is a joy to read and flows smoothly even in technical sections. The field of computational neuroscience desperately needs a book as well-written and thought out as this one." -- Joseph Atick, rockefeller University; Editor in Chief, Network: Computation In Neural Systems "Every now and again there is a book that is written with equal respect for the English language, the reader, and its subject matter. Spikes: Exploring the Neural Code is a pleasure. It deals with a fundamental issue in neuroscience -- how information about the world is represented in sensory spike trains -- how information about the world is represented in sensory spike trains -- and does so with clarity for the neuroscientist and rigor for the computational community. This book should become a classic in computational neuroscience." -- Eve Marder, Victor and Gwendolyn Beinfield Professor of Neuroscience, Volen Center and Department of Biology, Brandeis University " Spikes opens a valuable dialog about how neural codes are used as well as formed. It is wonderful to see such careful attention to the implications of individual spikes, both as elements of neural codes and as signals in their own right that have to be 'read out' to create perceptions. This is an excellent book that covers an important aspect of neuroscience and biophysics -- how the spike responses of neurons might be used to reconstruct information about the environment as well as organized to represent the stimulus. This is an exciting and rigorous book that explains with clarity and detail how widely-accepted neurophysiological results from several different sensory systems indicate that single spikes must count, and that response-rates and neuronal maps do not exhaust the properties needed to explain perception." -- James A. Simmons, Professor, Department of Neuroscience, Division of Biology and Medicine, Brown University "This monograph by Bialek and his group is a milestone in the analysis of the quantitative relationship between the firing of nerve cells (in the brain) and the amount of information they transmit. Drawing upon a wealth of physiological experiments, it makes the point that individual action potentials can convey one or more bits of information about the stimulus, permanently changing our attitude about the brain as a fuzzy computational soup that can only act via activity in an incountable number of neurons. This book will become a classic." -- Christof Koch, Professor of Computation and Neural Systems, California Institute of Technology Spikes is a really wonderful book. The particular theory about how the brain works that informs the presentation, and thus determines how neural coding is to be described, is clearly thought through and the arguments are attractively and intelligently presented. -- Charles F. Stevens, The Salk Institute

About the Author

Terrence J. Sejnowski holds the Francis Crick Chair at the Salk Institute for Biological Studies and is a Distinguished Professor at the University of California, San Diego. He was a member of the advisory committee for the Obama administration's BRAIN initiative and is President of the Neural Information Processing (NIPS) Foundation. He has published twelve books, including (with Patricia Churchland) The Computational Brain (25th Anniversary Edition, MIT Press). Tomaso A. Poggio is Eugene McDermott Professor in the Department of Brain and Cognitive Sciences at MIT, where he is also Director of the Center for Brains, Minds, and Machines and Codirector of the Center for Biological and Computational Learning. He is coeditor of Perceptual Learning (MIT Press).


A joy to read...This book will undoubtedly become a classic. The ideas presented in it have already begun (in no small part through the work of the authors) to reshape our views of the neural code. This book will make them accessible to a much wider audience.

-Anthony Zador

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