Table of Contents

1. Taxonomy and Evolution of Ion Channels 2. Voltage-Gated Sodium Channels 3. Voltage-Gated Calcium Channels 4. Voltage-Gated Potassium Channels 5. ERG Family of K Channels 6. KCNQ Channels 7. BK Channels 8. Small-Conductance Calcium-Activated Potassium (SK) Channels 9. Inward Rectifier Potassium Channels 10. Two-Pore Domain Potassium Channels 11. Cyclic Nucleotide-Gated Channels 12. HCN Channels 13. CLC Chloride Channels and Transporters 14. Ca-Activated Cl- Channels 15: Acetylcholine Receptors 16. Ionotropic Glutamate Receptors 17. 5-HT3 Receptors 18. GABAA Receptors 19. Glycine Receptors 20. Acid Sensing Ion Channels 21: ENaC Channels 22. TRPC Channels 23. TRPM Channels 24. TRPV Channels 25. Store-Operated CRAC Channels 26. Piezo Channels 27. Ryanodine Receptors 28. Proton Channels 29. P2X Receptors

About the Author

Jie Zheng, PhD, is a professor at the University of California Davis School of Medicine, where he has served as a faculty member in the Department of Physiology and Membrane Biology since 2004. Dr. Zheng earned a bachelor’s degree in physiology and biophysics (1988) and a master’s degree in biophysics (1991) at Peking University. He earned a PhD in physiology (1998) at Yale University, where he studied with Dr. Fredrick J. Sigworth on patch-clamp recording, single-channel analysis, and voltage-dependent activation mechanisms. He received his postdoctoral training at the Howard Hughes Medical Institute (HHMI) and the University of Washington during 1999–2003, working with Dr. William N. Zagotta on the cyclic nucleotide-gated channels activation mechanism and novel fluorescence techniques for ion channel research. Currently, Dr. Zheng’s research focuses on temperature-sensitive TRP channels.

Matthew C. Trudeau, PhD, is a professor in the Department of Physiology at the University of Maryland School of Medicine in Baltimore, Maryland. He earned a bachelor’s degree in biochemistry and molecular biology in 1992 and a PhD in physiology in 1998 while working with Gail Robertson, PhD, at the University of Wisconsin-Madison. His thesis work was on the properties of voltage-gated potassium channels in the human ether-aì-go-go related gene (hERG) family and the role of these channels in heart disease. Dr. Trudeau was a postdoctoral fellow with William Zagotta, PhD, at the University of Washington and the Howard Hughes Medical Institute (HHMI) in Seattle from 1998 to 2004, where he focused on the molecular physiology of cyclic nucleotide-gated ion channels, the mechanism of their modulation by calcium-calmodulin, and their role in an inherited form of vision loss. Currently, Dr. Trudeau’s work focuses on hERG potassium channels, their biophysical mechanisms, and their role in cardiac physiology and cardiac arrhythmias.