Table of Contents

Thrombin: Structure, Functions, and Regulation.- Thrombin: To PAR or Not to PAR, and the Regulation of Inflammation.- Regulation of Thrombin Receptor Signaling.- Thrombin-Activated Protein C: Integrated to Regulate Vascular Physiology.- The Role of Thrombin in Vascular Development.- The Role of Thrombin in Angiogenesis.- Thrombin and Thrombin Peptides in Wound Healing and Tissue Repair.- The Role of Thrombin and Thrombin Receptors in the Brain.- The Role of Thrombin in Tumor Biology.- The Role of Thrombin and its Receptors in Epithelial Malignancies: Lessons from a Transgenic Mouse Model and Transcriptional Regulation.- Anti-thrombotic Therapy in Cancer Patients.- Thrombin Receptor Modulators: Medicinal Chemistry, Biological Evaluation, and Clinical Application.- Novel Anticoagulant Therapy: Principle and Practice.