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Preface: Thrombin -- applied clinical biochemistry of the main factor of coagulation; Systemic thrombin in sepsis; Systemic thrombin, trypsin, or plasmin; Glucose provokes pathologic plasmatic thrombin generation; The maximal plasma concentration of (delta-) negatively charged contact triggers influences plasmatic thrombin generation; Thrombin generation by therapeutic immunoglobulins; Thrombin generation by ethosuximide; Thrombin generation by folic acid; Thrombin generation by diclofenac; Diagnostic ultrasound generates plasmatic thrombin.

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