Table of Contents

PART I: PRINCIPLES OF LABORATORY MEDICINE 1. Clinical Chemistry, Molecular Diagnostics, and Laboratory Medicine 2. Analytical and Clinical Evaluation of Methods 3. Preanalytical Variation 4. Biological Variation 5. Establishment and Use of Reference Values 6. Specimen Collection, Processing, and Other Preanalytical Variables 7. Quality Management 8. Principles of Basic Techniques and Laboratory Safety PART II: ANALYTICAL TECHNIQUES AND INSTRUMENTATION 9. Optical Techniques 10. Electrochemistry and Chemical Sensors 11. Electrophoresis 12. Chromatography 13. Mass Spectrometry 14. Enzyme and Rate Analyses 15. Immunochemical Techniques 16. Automation 17. Point-of-Care Testing PART III: ANALYTES 18. Amino Acids, Peptides, and Proteins 19. Serum Enzymes 20. Tumor Markers 21. Kidney Function Tests - Creatinine, GFR, Urea, and Uric Acid 22. Carbohydrates 23. Lipids, Lipoproteins, Apolipoproteins, and Other Cardiac Risk Factors 24. Electrolytes and Blood Gases 25. Hormones 26. Catecholamines and Serotonin 27. Vitaminsand Trace Elements, 28. Hemoglobin, Iron, and Bilirubin 29. Porphyrins and Porphyrias 30. Therapeutic Drug Monitoring 31. Clinical Toxicology 32. ToxicElements PART IV: PATHOPHYSIOLOGY 33. Diabetes Mellitus 34. Cardiovascular Disease 35. Kidney Disease 36. Physiology and Disorders of Water, Electrolyte, and Acid-Base Metabolism 37. Liver Disease 38. Gastrointestinal and Pancreatic Diseases 39. Disorders of Bone and Mineral Metabolism 40. Disorders of the Pituitary Gland 41. Disorders of the Adrenal Cortex 42. Thyroid Disorders 43. Reproduction-Related Disorders 44. Pregnancy and Prenatal Testing 45. Newborn Screening and Inborn Errors of Metabolism 46. Pharmacogenetics PART V: MOLECULAR DIAGNOSTICS 47. Molecular Principles 48. Molecular Techniques 49. Molecular Applications Appendix Reference Information for the Clinical Laboratory