Table of Contents

Section I. Cholinergic Drugs in Alzheimer’s Treatment.- Muscarinic Receptors:Molecular Biology and Neuropsychopharmacology.- Cholinomimetic Replacement of Cholinergic Function in Alzheimer Disease.- The Muscarinic Modulation of Acetylcholine Release from the Rat:Nostriatum Changes with Senescence.- Effects of Cholinergic Agents and Basal Forebrain Lesions in Rabbits.- Differential Effect of Aging on Hippocampal Pyramidal Cell Responses to Muscarine and Nicotine.- Modulation of Learning and Memory via Benzodiazepine Receptors:Potential Treatments for Age-related Dementia.- Acetylcholine-somatostatin Interactions:Potential Implications for the Treatment of Alzheimer’s Disease.- Section II. Growth Factors in Alzheimer’s Treatment.- The Role of Neurotrophins in the Central Nervous System:Significance for the Treatment of Neurodegenerative Diseases.- Contrasting Effects of Specific Lymphokines on the Survival of Hippocampal Neurons in Culture.- Growth Factor Regulation of Brain Protease Inhibitors.- Regulation of the Choline Acetyltransferase Gene.- Recombinant Human Nerve Growth Factor Increases Presynaptic Cholinergic Function Following Neuronal Damage:Implications for the Treatment of Alzheimer’s Disease.- Delayed Neuronal Death of Hippocampus (CA1) after Transient Global Ischemia:Does Nerve Growth Factor Protect Neurons Against “Killer Proteins?”.- Seizure-dependent Regulation of BDNF mRNA in the Rat Brain.- Section III. Phospholipids in Alzheimer’s Treatment.- Phosphatidylserine Stimulation of Macrophage Protein Secretion:Potential Healing and Trophic Mechanisms.- Pharmacological Effects of Phosphatidylserine in the Aging Rat Brain.- Effects of Phosphatidylserine in Age-associated Memory Impairment and Alzheimer’s Disease.- Section IV. Ion ChannelModulators in Alzheimer’s Disease.- Nimodipine Improves Learning and Sensorimotor Behaviors in Aging Mammals.- Cellular Mechanisms for Nimodipine’s Reduction of Aging-related Learning Deficits.- Selective Alterations in n-methyl-d-aspartate Receptor Coupled. Responses with Aging:Implications for Therapy.- Modulation of Frontal Cortical Acetylcholine Release by Benzodiazepine Receptor Ligands:Age-dependent Effects and Behavioral Correlates.- Section V. CNS Targeted Drug Delivery.- Enhanced Brain Delivery of Amino Acids and Peptides Through the Use of Redox Trageting Systems.- Brain Targeted Delivery of Neurotransmitters:Use of a Redox Based Chemical Delivery Stystem.- Procedures for Penetrating the Blood-brain-barrier:Studies of g-aminobutyric Acic (GABA).- Sendai Virosome Envelopes for the Infusion of Macromolecules into Brain Neurons and Glia.- Section VI. Normal Aging.- Oxidative Stress and the Loss of Muscarinic and Dopaminergic Responsiveness in Senescence.- Unique Aspects of Muscarinic Receptor Stimulated Inositol Polyphosphate Formation in Brain:Changes in Senescence.- Role of Aluminum and Iron in Brain Disorders.- RNA Metabolism in Human Brain During Aging and in Alzheimer’s Disease:RNA Synthesis in the Nuclei Isolated from Postmortem Brain Tissue.- Regulation of Glutamate Release in Aging.- Potential Therapeutic Use of Growth Hormone in the Metabolic Treatment of Alzheimer’s Disease.- Disturbed Body Weight Control in Geriatric Rats:A Model for Anorexia in Alzheimer’s.- Section VII. Animal Models for Alzheimer’s Disease.- Cholinergic Phenotype of Septal Cell Lines.- Selective Death of Cholinergic Septohippocampal Neurons Induced by Colchicine:The Role of Axoplasmic Transport.- Inhibition of Cytochrome Oxidase Impairs Learning and HippocampalPlasticity:A Novel Animal Model of Alzheimer’s Disease.- ß-Amyloid Peptides, Aluminum and Albumin.- Transmission Study of Neurofilament Pathology in Hamster Brain Produced by Alzheimer Buffy Coat Inoculation.

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