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This volume provides descriptions of the occurrence of the UPR, methods used to assess it, pharmacological tools and other methodological approaches to analyze its impact on cellular regulation

Table of Contents

Section I: New Approaches to Studying UPR and Cell Stress



CFTR Expression Regulation by the Unfolded Protein Response
Rafal Bartoszewski, Andras Rab, Lianwu Fu, Sylwia Bartoszewska, James Collawn and Zsuzsa Bebok
GRP78/BiP Chapter: Modulation of GRP78/BiP in Altering Sensitivity to Chemotherapy
Thomas C. Chen
Targeting the Unfolded Protein Response in Cancer Therapy
Marina V. Backer, Joseph M. Backer & Prakash Chinnaiyan
Large-scale analysis of UPR-mediated apoptosis in human cells
Andrew M. Fribley, Justin R. Miller, Tyler E. Reist1, Michael U. Callaghan and Randal J. Kaufman
Quantitative Analysis of amino acid oxidation markers by tandem mass spectrometry
Anuradha Vivekanandan-Giri, Jaeman Byun and Subramaniam Pennathur
Animal models in the study of the unfolded protein response
Hemamalini Bommiasamy and Brian Popko
Measurement of Fluoride-induced Endoplasmic Reticulum Stress Using Gaussia luciferase
Ramaswamy Sharma, Masahiro Tsuchiya, Bakhos A. Tannous and John D. Bartlett
Analysis of nelfinavir-induced endoplasmic reticulum stress
Ansgar Brüning
Using temporal genetic switches to synchronize the unfolded protein response in cell populations in vivo
Alexander Gow
Glycoprotein maturation and the UPR
Andreas J. Hülsmeier, Michael Welti and Thierry Hennet
Monitoring and Manipulating Mammalian Unfolded Protein Response
Nobuhiko Hiramatsu, Victory T. Joseph and Jonathan H. Lin
A screen for mutants requiring activation of the unfolded protein response for viability
Guillaume Thibault and Davis T.W. Ng
Signalling Pathways of Proteostasis Network Unrevealed By Proteomic Approaches on The Understanding of Misfolded Protein Rescue
Patrícia Gomes-Alves, Sofia Neves and Deborah Penque
Decreased Secretion and Unfolded Protein Response Up-Regulation
Carissa L. Young, Theresa Yuraszeck, Anne S. Robinson
Measuring signaling by the unfolded protein response
David Cox, Natalie Strudwick, Ahmed A. Ali, Adrienne W. Paton, James C. Paton, and Martin Schröder
Unfolded Protein Response
Jie Shang
Regulation of immunoglobulin synthesis, modification and trafficking by the unfolded protein response: a quantitative approach
Adi Drori and Boaz Tirosh
Use of Chemical Genomics in Assessment of the UPR
Sakae Saito, Akihiro Tomida
Small GTPase signalling and the Unfolded Protein Response
Marion Bouchecareilh, Esther Marza, Marie-Elaine Caruso and Eric Chevet
Inhibitors of advanced glycation and endoplasmic reticulum stress
Reiko Inagi

About the Author

P. Michael Conn is the Senior Vice President for Research and Associate Provost, Texas Tech Health Sciences Center. He was previously Director of Research Advocacy and Professor of Physiology and Pharmacology, Cell Biology and Development and Obstetrics and Gynecology at Oregon Health and Science University and Senior Scientist of the Oregon National Primate Research Center (ONPRC). He served for twelve years as Special Assistant to the President and Associate Director of the ONPRC. After receiving a B.S. degree and teaching certification from the University of Michigan (1971), a M.S. from North Carolina State University (1973), and a Ph.D. degree from Baylor College of Medicine (1976), Conn did a fellowship at the NIH, then joined the faculty in the Department of Pharmacology, Duke University Medical Center where he was promoted to Associate Professor in 1982. In 1984, he became Professor and Head of Pharmacology at the University of Iowa College of Medicine, a position he held for eleven years. Conn is known for his research in the area of the cellular and molecular basis of action of gonadotropin releasing hormone action in the pituitary and therapeutic approaches that restore misfolded proteins to function. His work has led to drugs that have benefitted humans and animals. He has authored or co-authored over 350 publications in this area and written or edited over 200 books, including texts in neurosciences, molecular biology and endocrinology. Conn has served as the editor of many professional journals and book series (Endocrinology, Journal of Clinical Endocrinology and Metabolism, Endocrine, Methods, Progress in Molecular Biology and Translational Science and Contemporary Endocrinology). Conn served on the National Board of Medical Examiners, including two years as chairman of the reproduction and endocrinology committee. The work of his laboratory has been recognized with a MERIT award from the NIH, the J.J. Abel Award of the American Society for Pharmacology and Experimental Therapeutics, the Weitzman, Oppenheimer and Ingbar Awards of the Endocrine Society, the National Science Medal of Mexico (the Miguel Aleman Prize) and the Stevenson Award of Canada. He is the recipient of the Oregon State Award for Discovery, the Media Award of the American College of Neuropsychopharmacology and was named a distinguished Alumnus of Baylor College of Medicine in 2012. He is an elected member of the Mexican Institute of Medicine and a fellow of the American Association for the Advancement of Science.