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Vaccine Adjuvants and Delivery Systems

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Table of Contents

Contributors vii Preface ix 1 Development of Vaccine Adjuvants: A Historical Perspective 1 Gary Ott and Gary Van Nest 2 Antigen Processing and Presentation 33 Subash Sad 3 Mechanisms of Adjuvant Action 53 Nils Lycke 4 Aluminum-Containing Adjuvants: Properties, Formulation, and Use 81 Stanley L. Hem and Harm HogenEsch 5 MF59: A Safe and Potent Oil-in-Water Emulsion Adjuvant 115 Derek T. O'Hagan and Manmohan Singh 6 TLR4 Agonists as Vaccine Adjuvants 131 David A. Johnson and Jory R. Baldridge 7 Immunostimulatory CpG Oligodeoxynucleotides as Vaccine Adjuvants 157 Dennis M. Klinman, Debbie Currie, and Hidekazu Shirota 8 Small Molecule Immunopotentiators as Vaccine Adjuvants 175 Fengfeng Xu, Nicholas M. Valiante, and Jeffrey B. Ulmer 9 New ISCOMs Meet Unsettled Vaccine Demands 191 Bror Morein, Kefei Hu, Karin Loevgren, and Erik D'Hondt 10 Surface-Charged Poly(lactide-co-glycolide) Microparticles as Novel Antigen Delivery Systems 223 Manmohan Singh, James Chesko, Jina Kazzaz, Mildred Ugozolli, Padma Malyala, and Derek T. O'Hagan 11 Liposomal Cytokines and Liposomes Targeted to Co-Stimulatory Molecules as Adjuvants for HIV Subunit Vaccines 249 Bulent Ozpolat and Lawrence B. Lachman 12 Archaeosome Vaccine Adjuvants for Cross-Priming CD8+T-Cell Immunity 263 Lakshmi Krishnan and G. Dennis Sprott 13 Mucosal Adjuvants and Delivery Systems 295 Michael Vajdy 14 Cytokines as Vaccine Adjuvants 327 Nejat K. Egilmez 15 Polyphosphazenes as Vaccine Adjuvants 355 Alexander K. Andrianov 16 Vaccine Delivery by Transdermal Electroporation 379 Amit Misra 17 Nonclinical Safety Assessment of Vaccines and the Evaluation of Novel Adjuvants and Delivery Systems 403 Jose A. Lebron, Jayanthi J. Wolf, Catherine V. Kaplanski, and Brian J. Ledwith 18 Safety Evaluation of Vaccine Adjuvants 421 Erik B. Lindblad Index 445

About the Author

MANMOHAN SINGH, M.Pharm., PhD, has worked in the area of vaccine adjuvants and delivery systems for seventeen years and has authored over eighty-five manuscripts and review articles. Dr. Singh is on the editorial board of five international journals and has contributed several book chapters. He is a Director of Vaccine Research within Novartis Vaccines.


"This book is very useful for understanding vaccines and their delivery systems." (Doody's Health Services)

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