PART I INTRODUCTION 1 Life, Cell and Thermodynamics 1

2 Physical and Chemical Properties of Water 23

PART II BIOMOLECULES 3 Overview of DNA Structure, Function, and Engineering 42

4 Amino Acids 805 Polypeptide Analysis, Sequencing and Evolution 976 Proteins: Structure and Folding 1317 Physiological Activities of Proteins 1808 Saccharide Chemistry 2219 Lipids, Bilayer and Membranes 24510 Passive and Active Transport 293

PART III ENZYMES 11 Mechanisms of Enzyme Action 322

12 Properties of Enzymes 36113 Hormones and Signal Transduction 402

PART IV METABOLISM 14 Bioenergetics 442

15 Glycolysis and the Pentose Phosphate Pathway 47816 Additional Pathways in Carbohydrate Metabolism 52317 The Citric Acid Cycle 55818 Mitochondrial ATP Synthesis 58819 Photosynthesis: Can be found at www.wiley.com/college/voet 20 Synthesis and Degradation of lipids 66421 Synthesis and Degradation of Amino Acids 71822 Regulation of Fuel Metabolism 773

PART V GENE EXPRESSION AND REPLICATION 23 Nucleotide Synthesis and Degradation 802

24 DNA structure and Interactions with Proteins 83125 DNA Synthesis and Repair 87926 RNA Metabolism 93827 The Genetic Code and Translation 98228 Gene Expression in Prokaryotes and Eukaryotes 1033Solutions: Can be found at www.wiley.com/college/voet Glossary G-1Index I-1

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