Table of Contents

VOLUME 1 PART I Laboratory Hematology CH 1. Examination of the Blood and Bone Marrow CH 2. Clinical Flow Cytometry CH 3. Cytogenetics CH 4. Molecular Biology and Hematology PART II The Normal Hematologic System Section 1. Hematopoiesis CH 5. Origin and Development of Blood Cells Section 2. The Erythrocyte CH 6. Erythropoiesis CH 7. The Mature Erythrocyte CH 8. Destruction of Erythrocytes Section 3. Granulocytes and Monocytes CH 9. Neutrophilic Leukocytes CH 10. The Human Eosinophil CH 11. Basophilic Leukocytes: Mast Cells and Basophils CH 12. Mononuclear Phagocytes CH 13. Phagocytosis Section 4. The Lymphocytes CH 14. Lymphocytes and Lymphatic Organs CH 15. B Lymphocytes CH 16. T Lymphocytes and Natural Killer Cells CH 17. Effector Mechanisms in Immunity Section 5. Hemostasis CH 18. Megakaryocytes CH 19. Platelet Structure and Function in Hemostasis and Thrombosis CH 20. Blood Coagulation and Fibrinolysis CH 21. Endothelium: Angiogenesis and the Regulation of Hemostasis PART III Therapeutic Modalities CH 22. Red Cell, Platelet, and White Cell Antigens CH 23. Transfusion Medicine CH 24. Hematopoietic Stem Cell Transplantation CH 25. Gene Therapy for Hematologic Disorders PART IV Disorders of Red Cells Section 1. Introduction CH 26. Anemia: General Considerations Section 2. Disorders of Iron Metabolism and Heme Synthesis CH 27. Iron Deficiency and Related Disorders CH 28. Sideroblastic Anemias CH 29. Hemochromatosis CH 30. Porphyria Section 3. Hemolytic Anemia CH 31. Hereditary Spherocytosis, Hereditary Elliptocytosis, and Other Disorders Associated with Abnormalities of the Erythrocyte Membrane CH 32. Hereditary Hemolytic Anemias Due to Red Blood Cell Enzyme Disorders CH 33. Autoimmune Hemolytic Anemia CH 34. Alloimmune Hemolytic Disease of the Fetus and Newborn CH 35. Paroxysmal Nocturnal Hemoglobinuria CH 36. Acquired Nonimmune Hemolytic Disorders Section 4. Hereditary Disorders of Hemoglobin Structure and Synthesis CH 37. Sickle Cell Anemia and Other Sickling Syndromes CH 38. Thalassemias and Related Disorders: Quantitative Disorders of Hemoglobin Synthesis CH 39. Hemoglobins with Altered Oxygen Affinity, Unstable Hemoglobins, M-Hemoglobins, and Dyshemoglobinemias Section 5. Other Red Cells Disorders CH 40. Megaloblastic Anemias: Disorders of Impaired DNA Synthesis CH 41. Inherited Aplastic Anemia Syndromes CH 42. Acquired Aplastic Anemia CH 43. Red Cell Aplasia CH 44. Congenital Dyserythropoietic Anemias CH 45. Anemias Secondary to Chronic Disease and Systemic Disorders CH 46. Anemias During Pregnancy and the Postpartum Period CH 47. Anemias Unique to the Newborn Period CH 48. Erythrocytosis V O L U M E 2 PART V Disorders of Hemostasis and Coagulation Section 1. Introduction Section 2. Thrombocytopenia Section 3. Other Disorders of Primary Hemostasis Section 4. Coagulation Disorders Platelet Destruction Section 5 Thrombosis PART VI Nonmalignant Disorders of Leukocytes,the Spleen, and/or Immunoglobins PART VII Hematologic Malignancies Section 1. General Aspects Section 2. The Acute Leukemias Section 4. Lymphoproliferative Disorders Section 5. Plasma Cell Dyscrasias Appendices INDEX

Reviews

Journal of the American Medical Association (JAMA), 09-DEC-09, Volume 302, Issue 22, Paulette Mehta, MD, MPH, Departments of Hematology/Oncology, University of Arkansas for Medical Sciences, Central Arkansas Veterans Healthcare System -- "This is the 12th and most complete iteration of Wintrobe's Clinical Hematology, first published in 1942 by Maxwell Meyer Wintrobe, a leading hematologist at that time. In the years since, the book has been updated, the science elaborated, and the number of editors expanded. Yet subsequent editions have retained the strength of the first edition...The current editorial team consists of the 5 experts who edited the previous edition, along with 2 new editors. All are experts in pediatric or adult hematology/hematopathology, and all are located in North America. More than 150 author-experts have contributed. "The book is encyclopedic in its coverage of biology and pathophysiology as well as of clinical practice. It is one of the largest hematology textbooks, comprising 2 volumes totaling 2606 pages. It offers an exhaustive panorama of diagrams, figures, standard and electron micrographs, algorithms, schemas, and protocols-all in color... "Chapters on hematologic malignancies are up to date and include new and potential future treatments. Treatment regimens are schematized and compared and contrasted with each other. For example, the protocols for leukemia are shown in parallel using color-coded blocks, making for easy and comparison of different regimens and helping clinicians to design their own protocols as needed based on benefits and toxicities. Juxtaposition of chromosome and genomic features with hematologic clinical features and prognoses are helpful for scientists and clinicians alike. The book is current and provides descriptions of novel agents and of emerging treatments in the pipeline. All chapters are consistent in style, format, and referencing. Figures abound-there are 1 to 5 figures per page, intermixed with the text. Tables are uniform in style throughout. "The book is accompanied by an electronic edition, also in full color, providing the complete text and all of the figures, schemas, and tables. The electronic content is fully searchable by topic, citation, author, or keyword. The tables and figures are useful for reviewing a chapter or presenting material to peers. Readers will find little information about geriatric hematology or stem cell transplantation; however, specialized textbooks are available in each of those topics. What readers of Wintrobe's Clinical Hematology will find is a comprehensive, encyclopedic, accurate, and authoritative review of classic hematology that exquisitely intertwines basic molecular biology with the clinical diagnosis and treatment of disease."-Journal of the American Medical Association (JAMA)