Table of Contents

mTORC1: A Signaling Integration Node Involved in Cell Growth.- The Regulation of the IGF-1/mTOR Pathway by the p53 Tumor Suppressor Gene Functions.- mTOR Signaling in Angiogenesis.- mTORC1 Signaling and Hypoxia.- mTOR Signaling in Glioblastoma: Lessons Learned from Bench to Bedside.- mTOR and Cancer Therapy: General Principles.- mTOR and Cancer Therapy: Clinical Development and Novel Prospects.- Drug Combinations as a Therapeutic Approach for mTORC1 Inhibitors in Human Cancer.- Downstream Targets of mTORC1.- Downstream of mTOR: Translational Control of Cancer.- Genome-Wide Analysis of Translational Control.- Translational Control of Cancer: Implications for Targeted Therapy.- Downstream from mTOR: Therapeutic Approaches to Targeting the eIF4F Translation Initiation Complex.